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DOI: 10.1055/a-2701-6195
Cobalt-Catalyzed C-2 Functionalization of N-Methylindole-1-carboxamide via Regioselective Hydroindolation of 1,6-Diyne
Autoren
We are thankful to NISER, the Department of Atomic Energy (DAE), IISER Tirupati, Science and Engineering Research Board (SERB), New Delhi (Grant CRG/2021/007153) for financial support.
Abstract
In this study, we present the novel reactivity of a cobalt(III) catalyst in the context of the functionalization of 1,6-diynes. Our mechanistic investigation reveals the intrinsic formation of a five-membered cobaltacycle, which subsequently undergoes migratory insertion with 1,6-diynes. Additionally, radical trapping studies provide compelling evidence supporting the involvement of an ionic pathway in this transformation. Furthermore, the deuterium exchange experiment lends further support to our proposed mechanism. Significantly, this methodology exhibits extensive versatility, accommodating a diverse array of electronically distinct substrates and reactive partners in a highly atom-efficient manner.
Keywords
Hydroindolation - 1,6-Diyne - Earth-abundant cobalt catalyst - C–H activation - Strong-chelationPublikationsverlauf
Eingereicht: 02. August 2025
Angenommen nach Revision: 14. September 2025
Accepted Manuscript online:
14. September 2025
Artikel online veröffentlicht:
21. Oktober 2025
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