A Catalyst-Free Transamination of (E)-N,N-Dimethyl Enaminones to β-Amino-α,β-Unsaturated Carbonyl Compounds by Using Isothiocyanates as Amines Proxy

Abstract

A facile synthesis of β-amino-α,β-unsaturated carbonyl compounds has been accomplished by the reaction of (E)-N,N-dimethyl enaminones with isothiocyanates under metal-, catalyst-, base-, and additive-free conditions. The reaction is straightforward and offers transamination with good substrate scope and functional group tolerance. Notably, the aryl isothiocyanates serve both as an amine surrogate as well as an activating agent.

Keywords

Transamination - Catalyst-free - Aryl isothiocyanates

Publikationsverlauf

Eingereicht: 25. Juni 2025

Angenommen nach Revision: 14. September 2025

Accepted Manuscript online:
14. September 2025

Artikel online veröffentlicht:
13. November 2025

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