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Synlett 2025; 36(19): 3250-3254
DOI: 10.1055/a-2680-2213
Letter

Unravelling the Synthesis of Benzo[d]imidazo[2,1-b]thiazoles via MnO2/I2-Catalyzed Ortoleva-King Type Approach

Autoren

  • Thaipparambil Aneeja

    1   School of Chemical Sciences, Mahatma Gandhi University, PD Hills, Kottayam, Kerala, India (Ringgold ID: RIN29318)

  • Padinjare Veetil Saranya

    1   School of Chemical Sciences, Mahatma Gandhi University, PD Hills, Kottayam, Kerala, India (Ringgold ID: RIN29318)

  • Gopinathan Anilkumar 

    1   School of Chemical Sciences, Mahatma Gandhi University, PD Hills, Kottayam, Kerala, India (Ringgold ID: RIN29318)
    2   Institute for Integrated Programs and Research in Basic Sciences (IIRBS), Mahatma Gandhi University, PD Hills, Kottayam, Kerala, India (Ringgold ID: RIN29318)

Funding Information No funding data available.
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Graphical Abstract

Dedication

Dedicated with profound reverence to Dr. Vijay Nair on the occasion of his first death anniversary.

Abstract

The first MnO2/I2-catalyzed one-pot synthesis of benzo[d]imidazo[2,1-b]thiazole from 2-aminobenzothiazole and aryl methyl ketone has been described. This methodology involves the in situ generation of α-iodoketone from aryl methyl ketone in the presence of a catalytic amount of molecular iodine. An array of aromatic ketones and 2-aminobenzothiazoles were compatible with this strategy, providing diverse fused benzoimidazothiazoles in moderate to good yields.

Keywords

Benzo[d]imidazo[2,1-b]thiazole - Aryl methyl ketone - 2-Aminobenzothiazole - Ortoleva-King type reaction - Manganese - Iodide source

Supplementary Material



Publikationsverlauf

Eingereicht: 24. Mai 2025

Angenommen nach Revision: 08. August 2025

Artikel online veröffentlicht:
26. August 2025

© 2025. Thieme. All rights reserved.

Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany

 

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