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Synthesis
DOI: 10.1055/a-2675-3869
DOI: 10.1055/a-2675-3869
Paper
Published as part of the Special Topic Dedicated to Prof. Paul Knochel
Synthesis of Symmetric and P-Stereogenic Self-Assembling Pyridone-Based Phosphorus Ligands
Gefördert durch: Albert-Ludwigs Universität
Dedication
Dedicated to Paul Knochel on the occasion of his 70th birthday.
Abstract
6-(Diphenylphosphino)pyridin-2(1H)-one (6-DPPon) is a unique ligand that can self-assemble in transition metal complexes. This self-assembly is achieved through hydrogen bonding interactions that mimic a bidentate coordination sphere. As a consequence, there is considerable interest in preparing derivatives of 6-DPPon and optimizing their synthesis. Herein, we present different methods for the preparation of self-assembling pyridone-based phosphorus ligands. Nineteen pyridone ligands were prepared using electrophilic and nucleophilic routes, including eleven P-stereogenic ligands.
Keywords
Ligand synthesis - Pyridone ligands - Self-assembly - P-stereogenic ligands - Phosphine chlorides - Bromine–lithium exchange - Crystal structurePublikationsverlauf
Eingereicht: 17. Juni 2025
Angenommen nach Revision: 03. August 2025
Accepted Manuscript online:
03. August 2025
Artikel online veröffentlicht:
12. September 2025
© 2025. Thieme. All rights reserved.
Georg Thieme Verlag KG
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