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Synlett
DOI: 10.1055/a-2669-6192
DOI: 10.1055/a-2669-6192
Account
Alkynes in Organic Synthesis
Alkyne-Based Cascade Strategies for the Construction of Diverse Carbo/Heterocycles
Autoren
This work is supported by the Science and Engineering Research Board (SERB) [File Number. CRG/2023/000775], Government of India.
Gefördert durch: Government of India
Gefördert durch: Indian Institute of Technology Hyderabad
Gefördert durch: University Grants Commission (UGC), New Delhi
Abstract
Carbocycles/heterocycles are fundamental structural motifs in natural products, pharmaceuticals, and functional materials. Alkyne-based cascade strategies have emerged as powerful tools for the efficient construction of these frameworks, enabling rapid access to diverse ring systems through domino cyclization pathways. This account highlights the representative recent advances of alkyne-mediated cascade reactions, covering transition-metal catalysis and acid-mediated reactions. These methods facilitate multiple bond-forming events in a single operation, offering high atom and step economy. Special focus is given to illustrative transformations, mechanistic insights, and the broad utility of alkynes as precursors for the concise synthesis of diverse carbocyclic and heterocyclic molecular frameworks.
Publikationsverlauf
Eingereicht: 30. Juni 2025
Angenommen nach Revision: 28. Juli 2025
Accepted Manuscript online:
29. Juli 2025
Artikel online veröffentlicht:
17. September 2025
© 2025. Thieme. All rights reserved.
Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany
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