Asymmetric Construction of the C(sp³)–SCF₃ Motif by CuH-Catalyzed Hydrofunctionalizations of 1-SCF₃-Alkenes

Abstract

Trifluoromethylthio (SCF₃)-containing molecules are highly valuable in medicinal chemistry and agrochemistry, and efficient synthetic methods for their preparation have thus been developed. However, the asymmetric construction of the C(sp³)–SCF₃ motif still remains largely underdeveloped. Herein, we summarize our recent work on the CuH-catalyzed hydrofunctionalizations of 1-SCF₃-alkenes, which enable the asymmetric synthesis of nontrivial C(sp³)–SCF₃ compounds that are difficult to prepare by other means.

Keywords

Asymmetric catalysis - Copper - Hydrofunctionalization - Organofluorine molecules - Trifluoromethylthio group

Publikationsverlauf

Eingereicht: 11. April 2025

Angenommen nach Revision: 04. Juli 2025

Accepted Manuscript online:
04. Juli 2025

Artikel online veröffentlicht:
30. Juli 2025

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