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DOI: 10.1055/a-2608-1808
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From Bio- to Surface-Orthogonal Chemistry: Synthetic Routes to Functionalized Cyclooctynes

Ulrich Koert 
1   Fachbereich Chemie, Philipps University, Marburg, Germany
,
Michael Dürr
2   Institut für Angewandte Physik and Zentrum für Materialforschung, Justus-Liebig-Universität Giessen, Giessen, Germany
,
Dominik Scharf
1   Fachbereich Chemie, Philipps University, Marburg, Germany
› Author AffiliationsSupported by: Deutsche Forschungsgemeinschaft SFB 1083 (project-A8, project ID 223848855)
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Syntheses of functionalized cyclooctynes for bio- and surface-orthogonal applications are described and compared. Points of interest are their chemoselective reactivity in cycloadditions and their compatibility with transannular side reactions. Applications of cyclooctynes for layer-by-layer-synthesis on the Si(001) surface are presented.



Publication History

Received: 03 April 2025

Accepted after revision: 14 May 2025

Accepted Manuscript online:
14 May 2025

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