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DOI: 10.1055/a-2589-4908
Metal-Free and Scalable Sulfoxide Reduction through the Couple (COCl)2/Et3SiH: Synthesis of Albendazole Hydrochloride
The authors thank the Chemistry Department of Universidad de Los Andes for financial support.
Abstract
Sulfides are valuable organic compounds and important synthetic intermediates. However, the reduction of sulfoxides to sulfides still lacks general applicability due to challenges such as harsh reaction conditions and the reliance on transition metal catalysts. Here, an extension of a previously reported metal-free reduction of sulfoxides is presented, incorporating a greener approach that, in most cases, eliminates the need for chromatographic purification. This method also enabled to scale up the reduction of albendazole to a multigram scale in excellent yield.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-2589-4908.
- Supporting Information
Publication History
Received: 24 February 2025
Accepted after revision: 16 April 2025
Accepted Manuscript online:
16 April 2025
Article published online:
14 May 2025
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