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Synthesis
DOI: 10.1055/a-2567-1329
DOI: 10.1055/a-2567-1329
short review
Transition-Metal-Catalyzed (Ni, Pd) Remote Difunctionalization of Alkenes via Chain-Walking Strategies
H.G. acknowledges the Robert A. Welch Foundation and Texas Tech University for financial support. K.Y. acknowledges Changzhou University for financial support.
Abstract
Alkenes are not only crucial feedstocks in the chemical industry but are also extensively present in natural products, pharmaceuticals, and organic functional materials. The direct difunctionalization of alkenes has emerged as a powerful and valuable strategy for the construction of highly functionalized organic skeletons. This short review highlights recent advancements in transition-metal-catalyzed remote 1,n-difunctionalization (n > 2) reactions of alkenes with the focus on innovative strategies involving chain-walking processes to construct complex, highly functionalized organic frameworks.
1 Introduction
2 Nickel Catalysis
3 Palladium Catalysis
4 Conclusion
Key words
nickel catalysis - palladium catalysis - remote difunctionalization - alkenyl derivatives - chain-walkingPublication History
Received: 28 February 2025
Accepted after revision: 26 March 2025
Accepted Manuscript online:
26 March 2025
Article published online:
05 May 2025
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