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Synthesis
DOI: 10.1055/a-2567-1329
short review

Transition Metal (Ni, Pd)-Catalyzed Remote Difunctionalization of Alkenes via Chain-Walking Strategies

Dan Yuan
1   School of Petrochemical Engineering, Changzhou University, Changzhou, China (Ringgold ID: RIN12412)
,
Chong Liu
2   Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, United States (Ringgold ID: RIN6177)
,
Fahima Jahan Achal
2   Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, United States (Ringgold ID: RIN6177)
,
Md Sajib Joardar
2   Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, United States (Ringgold ID: RIN6177)
,
Ke Yang
1   School of Petrochemical Engineering, Changzhou University, Changzhou, China (Ringgold ID: RIN12412)
,
Haibo Ge 
3   Chemistry and Biochemistry, Texas Tech University System, Lubbock, United States (Ringgold ID: RIN148514)
› Author AffiliationsSupported by: Welch Foundation D-2034-20230405
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Alkenes are not only crucial feedstocks in the chemical industry but are also extensively present in natural products, pharmaceuticals, and organic functional materials. The direct difunctionalization of alkenes has emerged as a powerful and valuable strategy for the construction of highly functionalized organic skeletons. This Short Review highlights recent advancements in transition metal-catalyzed remote 1,n-difunctionalization (n > 2) reactions of alkenes with the focus on innovative strategies involving chain-walking processes to construct complex, highly functionalized organic frameworks.



Publication History

Received: 28 February 2025

Accepted after revision: 26 March 2025

Accepted Manuscript online:
26 March 2025

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