Synthesis of Dimeric Hybrid Steroid Trioxadispiroketals by Cadiot–Chodkiewicz Coupling/Gold-Catalyzed Dispiroketalization

Abstract

Two hybrid steroids dimers bearing the trioxadiespiroketal moiety were obtained starting from cholesterol and diosgenin. The key steps of the designed protocol are the Cadiot–Chodkiewicz cross coupling between iodoalkynols and alkynols and the Au-catalyzed dispiroketalization of hybrid dialkyndiols.

Key words

hybrid steroid dimers - trioxadispiroketals - palladium catalysis - gold catalysis - NMR - X-ray diffraction

Publikationsverlauf

Eingereicht: 30. Januar 2025

Angenommen nach Revision: 19. März 2025

Accepted Manuscript online:
19. März 2025

Artikel online veröffentlicht:
23. April 2025

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