Synthesis of Dimeric Hybrid Steroid Trioxadispiroketals by Cadiot–Chodkiewicz Coupling/Gold-Catalyzed Dispiroketalization

Abstract

Two hybrid steroids dimers bearing the trioxadiespiroketal moiety were obtained starting from cholesterol and diosgenin. The key steps of the designed protocol are the Cadiot–Chodkiewicz cross coupling between iodoalkynols and alkynols and the Au-catalyzed dispiroketalization of hybrid dialkyndiols.

Key words

hybrid steroid dimers - trioxadispiroketals - palladium catalysis - gold catalysis - NMR - X-ray diffraction

Publication History

Received: 30 January 2025

Accepted after revision: 19 March 2025

Accepted Manuscript online:
19 March 2025

Article published online:
23 April 2025

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