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Synthesis 2025; 57(12): 2004-2014
DOI: 10.1055/a-2562-8973
DOI: 10.1055/a-2562-8973
paper
Synthesis of Dimeric Hybrid Steroid Trioxadispiroketals by Cadiot–Chodkiewicz Coupling/Gold-Catalyzed Dispiroketalization
The authors acknowledge the financial support provided by Dirección General de Asuntos del Personal Académico (Grant IN204323) and the Faculty of Chemistry UNAM (PAIP-5000-9063).
Abstract
Two hybrid steroids dimers bearing the trioxadiespiroketal moiety were obtained starting from cholesterol and diosgenin. The key steps of the designed protocol are the Cadiot–Chodkiewicz cross coupling between iodoalkynols and alkynols and the Au-catalyzed dispiroketalization of hybrid dialkyndiols.
Key words
hybrid steroid dimers - trioxadispiroketals - palladium catalysis - gold catalysis - NMR - X-ray diffractionSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-2562-8973.
- Supporting Information
Publication History
Received: 30 January 2025
Accepted after revision: 19 March 2025
Accepted Manuscript online:
19 March 2025
Article published online:
23 April 2025
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