Recent Advances in the Chemistry and Application of SF₅-Compounds

Abstract

This review article outlines the literature from 2022 to 2024 covering developments in SF₅ chemistry. Recent synthetic methodologies of SF₅-containing building blocks are reported. These methods include the synthesis of SF₅Cl and its use in pentafluorosulfanylation reactions and oxidative fluorination reactions. Moreover, the reactivity of SF₅-alkynes as versatile platform to access new SF₅-compounds is described. Finally, the effects of the SF₅ moiety are highlighted according to its application in different fields, such as biological/medicinal chemistry, catalysis, and material sciences.

1 Introduction

2 Access to SF₅-Containing Building Blocks

2.1 By Means of SF₅Cl

2.1.1 Generation of SF₅Cl

2.2 By Means of Oxidative Fluorination

2.3 By Means of SF₅-Alkynes

2.4 Other Miscellaneous Aromatic and Aliphatic SF₅-Compounds

3 Applications

3.1 Medicinal and Biological Chemistry

3.2 Material Science

3.3 Catalysis

4 Conclusion

Key words

SF₅Cl - pentafluorosulfanylation - SF₅ building blocks - oxidative fluorination - medicinal chemistry - materials science - catalysis

Publication History

Received: 08 July 2024

Accepted after revision: 09 August 2024

Accepted Manuscript online:
09 August 2024

Article published online:
26 September 2024

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