Synlett 2024; 35(08): 877-882
DOI: 10.1055/a-2290-6711
account
Special Issue dedicated to Keith Fagnou

Towards Catalytic C–H Activation Using Main Group Elements

Prof. McNally acknowledges the Albert I. Meyers Foundation for support.


This Account is dedicated to the memory of Keith Fagnou.

Abstract

Catalytic C–H activation reactions are now established as a means to directly transform organic molecules and are commonly associated with metals such as palladium, rhodium, ruthenium and iridium. This Account will describe a short number of reports demonstrating that structures containing main group elements can facilitate C–H activation processes. In particular, boron-based catalysts can promote catalytic arene C–H borylation reactions, and an emerging approach using phosphenium ions can also cleave sp2 C–H bonds. These processes use a Lewis acidic main group atom combined with a pendant base to cleave C–H bonds, which compares with metal-catalyzed reactions that proceed via concerted metalation deprotonation mechanisms.

1 Introduction

2 Metal-Catalyzed C–H Activation via CMD/AMLA Mechanisms

3 C–H Borylation via Boron-Based Catalysts

4 C–H Activation Using Phosphenium Ions

5 Conclusions



Publication History

Received: 16 February 2024

Accepted after revision: 19 March 2024

Accepted Manuscript online:
19 March 2024

Article published online:
05 April 2024

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