Synlett 2024; 35(08): 840-850
DOI: 10.1055/a-2193-2682
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Special Issue dedicated to Keith Fagnou

Photoredox-Catalyzed C(sp2)–H Bond Functionalization Reactions: A Short Account

Jinling Li
a   College of Advanced Interdisciplinary Science and Technology, Henan University of Technology, Zhengzhou, 450001, P. R. of China
,
Junjie Zhao
a   College of Advanced Interdisciplinary Science and Technology, Henan University of Technology, Zhengzhou, 450001, P. R. of China
,
Teck-Peng Loh
a   College of Advanced Interdisciplinary Science and Technology, Henan University of Technology, Zhengzhou, 450001, P. R. of China
b   Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 637371, Singapore, Singapore
› Author Affiliations
We gratefully acknowledge the financial support from the Training Plan for Young Backbone Teachers in Higher Education Institutions of Henan Province in 2019 (2019GGJS093). We also gratefully acknowledge the financial support from the Distinguished University Professor grant (Nanyang Technological University), AcRF Tier 1 grants from the Ministry of Education of Singapore (RG11/20 and RT14/20), and the Agency for Science, Technology and Research (A*STAR) under its MTC Individual Research Grants (M21K2c0114).


Abstract

Photoredox catalysis has been undergoing rapid development and wide application in the chemical community during the past several years because of its advantages for reaction engineering. Since 2016, Loh et al. started their research on photoredox-catalyzed reaction transformations, including β-C(sp2)–H fluoroalkylation, alkylation, and acylation of enamides, C(sp2)–H phosphorylation of alkenes converted from alcohols, C(sp2)–H bromination, and alkylation of (hetero)arenes. These transformations introduce a broad range of structural differences on the C(sp2)–H bond of compounds with an extensive array of functional groups and showcase the appealing synthetic utilities of the approach.

1 Introduction

2 Photoredox-Catalyzed β-C(sp2)–H Functionalization of Enamides

3 Photoredox-Catalyzed C(sp2)–H Functionalization of Alkenes

4 Photoredox-Catalyzed C(sp2)–H Functionalization of (Hetero)Arenes

5 Conclusion



Publication History

Received: 03 September 2023

Accepted after revision: 17 October 2023

Accepted Manuscript online:
17 October 2023

Article published online:
27 November 2023

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