Abstract
The Myrioneuron alkaloids are a relatively small family of plant-derived alkaloids that present an
intriguing array of structural intricacy and biological properties. As such, these
natural products have drawn interest from the synthetic community, resulting in creative
total syntheses of several family members. This review showcases recent synthetic
efforts towards these polycyclic alkaloids.
1 Introduction
1.1 Biological Activity
1.2 Proposed Biosynthesis
2 Synthetic Studies toward the Myrioneuron Alkaloids
2.1 Total Synthesis of Myrioxazines A and B
2.2 Total Synthesis of Myrionine, Myrionidine, and Schoberine
2.3 Total Synthesis of Myrifabrals A and B
2.4 Total Synthesis of Myrioneurinol
3 Conclusions and Outlook
Key words
alkaloids - total synthesis - Myrioneuron - asymmetric synthesis - biosynthesis
