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CC BY-NC-ND 4.0 · Synthesis 2023; 55(03): 417-432
DOI: 10.1055/a-1944-9623
short review

Total Synthesis of Geranyl-Resorcinols Isolated from Mushrooms of Genus Hericium

Shoji Kobayashi  ∗
This work was supported by Japan Society for the Promotion of Science (JSPS) KAKENHI Grant Number 21K05407.
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Abstract

This Short Review covers the total synthesis of tetraketide-based meroterpenoids, i.e. geranyl-resorcinols, isolated from the mushrooms of genus Hericium. Some of these compounds are believed to be involved in the unique health-promoting effects of Hericium erinaceus. Herein, more than seventy natural products identified so far have been classified into seven-types based on both assumed biosynthetic pathways and chemical structures, and the successful total syntheses are summarized according to the structural type.

1 Introduction

2 Pioneering Synthetic Study

3 Total Synthesis of Geranyl-Resorcinol with a Geranyl Side Chain (Types 1, 3, and 6)

4 Total Synthesis of Geranyl-Resorcinol with an Oxidized Geranyl-Derived Side Chain (Types 2, 4, and 7)

5 Conclusion

Key words

mushroom - Hericium erinaceus - meroterpenoid - geranyl-resorcinol - total synthesis - biosynthetic pathway


Publication History

Received: 01 August 2022

Accepted after revision: 15 September 2022

Accepted Manuscript online:
15 September 2022

Article published online:
28 November 2022

© 2022. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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