Dedicated to Professor Alain Krief on the occasion of his 80th birthday
Abstract
In the last few decades, there has been an increasing interest in the development
of new syntheses of oxazinoindoles, a tricyclic backbone bearing an indole core structure
fused with a morpholine ring, in particular because these molecules have interesting
bioactive properties, such as antidepressant, anti-inflammatory, or antitumor activity.
There are a few reported racemic strategies for the synthesis of oxazinoindoles, but
only four reports of enantioselective syntheses. This short review presents an overview
of these enantioselective strategies as well as the evaluation of chiral oxazinoindoles
for their bioactive properties.
1 Introduction
2 Racemic Syntheses and Evaluation of Chiral Oxazinoindoles after Separation
3 Enantioselective Catalytic Syntheses of Oxazinoindoles
4 Conclusion
Key words
oxazinoindoles - bioactive molecules - chirality - chiral separation - asymmetric
syntheses
