Synlett
DOI: 10.1055/a-1787-1159
synpacts

The Conceptual Development of a Conjunctive Olefination

Dario Filippini
a   GSK Carbon Neutral Laboratories for Sustainable Chemistry, University of Nottingham, Jubilee Campus, 6 Triumph Rd, Nottingham NG7 2GA, UK
b   School of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, UK
,
Mattia Silvi
a   GSK Carbon Neutral Laboratories for Sustainable Chemistry, University of Nottingham, Jubilee Campus, 6 Triumph Rd, Nottingham NG7 2GA, UK
b   School of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, UK
› Author Affiliations
We thank the Engineering and Physical Sciences Research Council (EPSRC, New Investigator Award, Grant Number EP/V006401/1 to M.S.) for funding. M.S. thanks the University of Nottingham and the Green Chemicals Beacon of Excellence for a Nottingham Research Fellowship. D.F. thanks the School of Chemistry, University of Nottingham, for a doctoral fellowship.


Abstract

We recently discovered a functional group tolerant and transition-metal-free conjunctive olefination reaction with applications in late-stage functionalization chemistry. In this Synpacts contribution, we analyze the conceptual background that has stimulated the discovery of this reactivity and reflect on the key aspects of its development.

1 Introduction

2 Conceptual Background

2.1 Photoredox-Mediated Giese Reaction

2.2 Photoredox Radical-Polar Reactivity

3 The Development of the Process

4 Conclusion



Publication History

Received: 24 February 2022

Accepted after revision: 03 March 2022

Publication Date:
03 March 2022 (online)

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