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Synthesis 2022; 54(04): 1043-1054
DOI: 10.1055/a-1703-6448
DOI: 10.1055/a-1703-6448
special topic
Cycloadditions – Established and Novel Trends – in Celebration of the 70th Anniversary of the Nobel Prize Awarded to Otto Diels and Kurt Alder
Ascending of Cycloaddition Strategy for N–O Heterocycles
P.G. acknowledges the Science and Engineering Research Board (SERB) for a NPDF (PDF/2017/000449) and S.M. also acknowledges the Council of Scientific and Industrial Research, India (CSIR) for a JRF. M.B. thanks the Indian Institute of Technology Madras (IIT-Madras) for Institute Research Development Award (IRDA) and funding support through IOE project grant.
Abstract
The N–O heterocycles are biologically relevant scaffolds and versatile building blocks in contemporary organic synthesis. In this short review, we showcase the involvement and elevation of various cycloaddition strategies towards the production of the N–O heterocycles; 1,2-oxazines and 1,2-oxazinanes, 1,2-oxazepanes, and 1,2-oxazetidines. An overview of the advantages and challenges associated with these synthetic endeavors is provided.
1 Introduction
2 Six-Membered N–O Heterocycles (1,2-Oxazines and 1,2-Oxazinanes)
3 Seven-Membered N–O Heterocycles (1,2-Oxazepanes)
4 Four-Membered N–O Heterocycles (1,2-Oxazetidines)
5 Summary and Outlook
Key words
cycloaddition - nitroso Diels–Alder reaction - nitrones - oxazines - oxazetidines - oxazepane - cyclopropanes - cascade reactionPublication History
Received: 21 October 2021
Accepted after revision: 23 November 2021
Accepted Manuscript online:
23 November 2021
Article published online:
12 January 2022
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