Synthesis 2022; 54(21): 4795-4801
DOI: 10.1055/a-1662-7096
special topic
Asymmetric C–H Functionalization

Asymmetric C–H Functionalization Enabled by Pd/Chiral Phosphoric Acid Combined Catalysis

Pu-Sheng Wang
a   Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, 230026, P. R. of China
,
Liu-Zhu Gong
a   Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, 230026, P. R. of China
b   Center for Excellence in Molecular Synthesis of Chinese Academy of Sciences, Hefei 230026, P. R. of China
› Institutsangaben
We are grateful for financial support from the Ministry of Science and Technology of the People’s Republic of China (2015CB856600), the National Natural Science Foundation of China (NSFC, 21831007 and 21672197) and Youth Innovation Promotion Association of the Chinese­ Academy of Sciences is gratefully acknowledged.


Abstract

Over the past decade, the combination of chiral phosphoric acid and palladium catalysis has emerged as a robust strategy to accomplish the regio- and stereoselective functionalization of inactive C–H bonds, enabling access to various types of chirality (central, planar, and axial). This review article describes the origin and advances in the asymmetric functionalization of allylic C–H, C(sp2)–H, and C(sp3)–H bonds enabled by chiral phosphoric acid and palladium combined catalysis.

1 Introduction

2.1 Enantioselective Allylic C–H Functionalization

2.2 Enantioselective Non-allylic C(sp3)–H Functionalization

2.3 Enantioselective C(sp2)–H Functionalization

3 Conclusion



Publikationsverlauf

Eingereicht: 07. September 2021

Angenommen nach Revision: 06. Oktober 2021

Accepted Manuscript online:
06. Oktober 2021

Artikel online veröffentlicht:
22. November 2021

© 2021. Thieme. All rights reserved

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 
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