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Synthesis 2022; 54(03): 655-657
DOI: 10.1055/a-1648-7074
DOI: 10.1055/a-1648-7074
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A Convenient Procedure for Sonogashira Reactions Using Propyne
Authors
This work was supported by the U.S. Department of Energy (DOE), Office of Biological and Environmental Research, Biological Systems Science Division under FWP# AL-18-380-055 to the Ames Laboratory. The Ames Laboratory is operated for the U.S. Department of Energy by Iowa State University under Contract No. DE-AC02-07CH11358.
Abstract
A modified Sonogashira coupling of aryl iodides and propyne was achieved using only two equivalents of propyne in THF from –78 °C to room temperature.
Publication History
Received: 19 August 2021
Accepted after revision: 20 September 2021
Accepted Manuscript online:
20 September 2021
Article published online:
21 October 2021
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