Synthesis 2021; 53(19): 3535-3544
DOI: 10.1055/a-1493-6670
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Aza-Peterson Olefinations: Rapid Synthesis of (E)-Alkenes

Thomas K. Britten
,
Ashley J. Basson
,
Dean D. Roberts
,
We thank Manchester Metropolitan University (MMU) for startup funding. T.K.B. thanks MMU for Strategic Opportunities Funding. M.G.M. thanks MMU, Royal Society of Chemistry and Medical Research Council for funding.


Abstract

An aza-Peterson olefination methodology to access 1,3-dienes and stilbene derivatives from the corresponding allyl- or benzyltrimethylsilane is described. Silanes can be deprotonated using Schlosser’s base and added to N-phenyl imines or ketones to directly give the desired products in high yields.

Supporting Information



Publikationsverlauf

Eingereicht: 31. März 2021

Angenommen nach Revision: 28. April 2021

Accepted Manuscript online:
28. April 2021

Artikel online veröffentlicht:
25. Mai 2021

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