Ferrocenesulfonyl chloride is the key intermediate in the synthesis of ferrocenesulfonamides,
a family of underexplored derivatives. A one-pot synthesis of this compound, able
to easily deliver multigram quantities of product, is reported. An original protocol
for the synthesis of ferrocenesulfonamides is described along with highlighting the
reactivity difference between arene and ferrocenesulfonyl chlorides. Finally, an example
of diastereoselective deprotolithiation of chiral ferrocenesulfonamides is described.
Key words
ferrocene - sulfonyl chloride - sulfonamide - scale-up - diastereoselective deprotolithiation