Total Mycosynthesis: Rational Bioconstruction and Bioengineering of Fungal Natural Products

Abstract

Total biosynthesis in fungi is beginning to compete with traditional chemical total synthesis campaigns. Herein, the advantages, disadvantages and future opportunities are discussed within the scope of several recent examples.

1 Introduction

2 Synthetic Examples

2.1 2-Pyridones

2.2 Cytochalasans

2.3 Sorbicillinoids

2.4 Decalins: Solanapyrone

2.5 α-Pyrone Polyenes: Citreoviridin and Aurovertin

2.6 Anditomin and Related Meroterpenoids

2.7 Tropolone Sesquiterpenoids

3 Conclusion

Key words

pyridone - cytochalasan - sorbicillinoid - decalin - α-pyrone - meroterpenoid - tropolone sesquiterpenoid

Publication History

Received: 07 January 2021

Accepted after revision: 26 February 2021

Accepted Manuscript online:
26 February 2021

Article published online:
16 March 2021

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