Synthesis 2021; 53(14): 2381-2394
DOI: 10.1055/a-1401-2716
short review

Total Mycosynthesis: Rational Bioconstruction and Bioengineering of Fungal Natural Products

Lukas Kahlert
a  Institute for Organic Chemistry, Leibniz University of Hannover, Schneiderberg 1a, 30167, Hannover, Germany
b  BMWZ, Schneiderberg 38, 30167, Hannover, Germany
,
Carsten Schotte
a  Institute for Organic Chemistry, Leibniz University of Hannover, Schneiderberg 1a, 30167, Hannover, Germany
b  BMWZ, Schneiderberg 38, 30167, Hannover, Germany
,
a  Institute for Organic Chemistry, Leibniz University of Hannover, Schneiderberg 1a, 30167, Hannover, Germany
b  BMWZ, Schneiderberg 38, 30167, Hannover, Germany
› Author Affiliations
R.J.C. acknowledges support from DFG in Germany and EPSRC and BBSRC in the UK for project funding. Long-term support has been provided by the universities of Hannover and Bristol, and collaborations with Glaxo, Syngenta and Bayer are gratefully acknowledged. L.K. is funded by DFG (CO 1328/5-1) and C.S. by Leibniz Universität Hannover.


Abstract

Total biosynthesis in fungi is beginning to compete with traditional chemical total synthesis campaigns. Herein, the advantages, disadvantages and future opportunities are discussed within the scope of several recent examples.

1 Introduction

2 Synthetic Examples

2.1 2-Pyridones

2.2 Cytochalasans

2.3 Sorbicillinoids

2.4 Decalins: Solanapyrone

2.5 α-Pyrone Polyenes: Citreoviridin and Aurovertin

2.6 Anditomin and Related Meroterpenoids

2.7 Tropolone Sesquiterpenoids

3 Conclusion



Publication History

Received: 07 January 2021

Accepted after revision: 26 February 2021

Publication Date:
26 February 2021 (online)

© 2021. Thieme. All rights reserved

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 
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