Synthesis 2021; 53(14): 2342-2366
DOI: 10.1055/a-1394-7511
short review

Recent Advances in the Synthesis of Heterocycles by the Aza-Wittig Reaction

Keyvan Pedrood
a  Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
,
Mohammad Nazari Montazer
b  Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
,
Bagher Larijani
a  Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
,
a  Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
› Author Affiliations


Abstract

The formation of the C=N bond in recent studies on heterocyclic compounds via the aza-Wittig reaction is reviewed. Furthermore, two different strategies for the formation of heterocyclic compounds, including intermolecular and intramolecular aza-Wittig reactions are described. The primary aim of this review is to provide up-to-date information on the application of the aza-Wittig reaction in the synthesis of a wide range of N-containing heterocyclic compounds in the chemical literature since 2010.

1 Introduction

2 Mechanism of the Staudinger and Aza-Wittig Reactions

3 Intramolecular Aza-Wittig Reaction

4 Intermolecular Aza-Wittig Reaction

5 Conclusion



Publication History

Received: 13 December 2020

Accepted after revision: 18 February 2021

Publication Date:
18 February 2021 (online)

© 2021. Thieme. All rights reserved

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 
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