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Synlett 1994; 1994(10): 836-838
DOI: 10.1055/s-1994-23023
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Synthesis of Cyclic Imines by Addition of Grignard Reagents to ω-Bromonitriles

Douglas F. Fry* , Carol B. Fowler, R. Karl Dieter
  • *Departments of Chemistry, Erskine College, Due West, SC 29639, USA and Clemson University, SC 29634-1905, USA
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Publication Date:
22 March 2002 (online)

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ω-Bromonitriles readily undergo a tandem addition-cyclization reaction sequence with Grignard reagents at room temperature in hydrocarbon/ether solvent mixtures to give good yields of 2-substituted pyrrolines and tetrahydropyridines.