Vinylation of Benzylic Amines via C–N Bond Functionalization of Benzylic Pyridinium Salts

Weiye Guan; Jennie Liao; Mary P. Watson

doi:10.1055/s-0037-1610084

Synthesis, Inhaltsverzeichnis

Synthesis 2018; 50(16): 3231-3237
DOI: 10.1055/s-0037-1610084

special topic

Vinylation of Benzylic Amines via C–N Bond Functionalization of Benzylic Pyridinium Salts

Authors

Weiye Guan

Department of Chemistry and Biochemistry, University of Delaware, Newark, DE 19716, USA eMail: mpwatson@udel.edu
Jennie Liao

Department of Chemistry and Biochemistry, University of Delaware, Newark, DE 19716, USA eMail: mpwatson@udel.edu
Mary P. Watson *

Department of Chemistry and Biochemistry, University of Delaware, Newark, DE 19716, USA eMail: mpwatson@udel.edu

Abstract

Alle Artikel dieser Rubrik

^‡ W.G. and J.L. are co-first authors.

Published as part of the Special Topic Modern Coupling Approaches and their Strategic Applications in Synthesis

Abstract

Cross-couplings of benzylic pyridinium salts and vinylboronic acids or esters have been developed. Via benzylic pyridinium intermediates, benzylic amines can be engaged in these cross-couplings through C–N bond functionalization. This method boasts mild reaction conditions and excellent tolerance for heteroaryl substituents and a range of functional groups.

Key words

allyl complexes - amines - benzylation - catalysis - cross-coupling - nickel

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Referenzen

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