A Neutral FeCl₃ Photocatalysis for C–C Bond Animation and Alkylation of Cyclic Alcohols

Abstract

A modified method for iron-catalyzed C–C bond cleavage and amination and alkylation of nonactivated cyclic alcohols has been developed. Using FeCl₃ as catalyst, the photoinduced ligand-to-metal charge transfer facilitates the generation of O-radicals from alcohols, the subsequent β-scission, and finally the radical trapping. Compared with the Fe(OR)₃ catalysis, this mildly base-free system could enable the amination in a broader substrate scope with higher yields. Moreover, the C–C bond cleavage and alkylation of cyclic alcohols proceeds with electron-deficient olefins under these conditions.

Key words

iron catalysis - photocatalysis - C–C bond cleavage - amination - alkylation

Publikationsverlauf

Eingereicht: 16. September 2022

Angenommen nach Revision: 24. Oktober 2022

Accepted Manuscript online:
24. Oktober 2022

Artikel online veröffentlicht:
24. November 2022

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