Download PDF
Synthesis 2004(7): 1037-1040  
DOI: 10.1055/s-2004-822342
PAPER
© Georg Thieme Verlag Stuttgart · New York

Enantiomeric Synthesis of the SPIKET-P Enantiomers

Anubha Sharma, Prema Iyer, Sunita Gamre, Subrata Chattopadhyay*
Bio-Organic Division, Bhabha Atomic Research Centre, Mumbai - 400 085, India
Fax: +91(22)5505151; e-Mail: schatt@apsara.barc.ernet.in;
Further Information

Publication History

Received 11 February 2004
Publication Date:
14 April 2004 (online)

    Permissions and Reprints All articles of this category

Abstract

A convenient synthesis of the antipodes of the title compound has been developed starting from (R)-1,2,5,6-dicyclohexylidene mannitol. Some of the key features of the syntheses were simple reaction protocols, and stereoselective inversion of chiral 1,2-diol moiety via neighbouring group assisted acetylation.

Keywords

cytotoxic - (R)-1,2,5,6-dicyclohexylidene mannitol - enantiomeric synthesis