Synthesis 2000; 2000(3): 329-351
DOI: 10.1055/s-2000-6333
review
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Synthesis of Acyclovir, Ganciclovir and Their Prodrugs: A Review

Hongwu Gao* , Ashim K. Mitra
  • *Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, 5050 Rockhill Road, Kansas City, MO 64110-2499, USA; Fax +1 (8 16) 2 35 51 90; E-mail: mitraa@umkc.edu
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Publikationsverlauf

Publikationsdatum:
31. Dezember 2000 (online)

This review article deals with the synthetic methods of acyclovir, ganciclovir and their prodrugs. Based on the starting materials, three main routes to acyclovir and ganciclovir are described, including N 9-regioselective synthesis. Prodrug approaches to increase the bioavailability included esterification, phosphorylation of acyclic fragment and oxidation of 6-deoxy acyclovir by xanthine oxidase.

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