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Synthesis 1998; 1998(4): 379-380
DOI: 10.1055/s-1998-4486
short paper
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Mild Conditions for Oxazolidin-5-one Formation

Mark A. Blaskovich* , Michael Kahn
  • *Molecumetics Institute, 2023 120th Ave N.E., Suite 400, Bellevue, WA 98005-2199, USA
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Publication History

Publication Date:
31 December 2000 (online)

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A variety of acid-catalyzed conditions for oxazolidin-5-one formation from Fmoc protected amino acids and paraformaldehyde have been examined. Good yields of cyclized monosubstituted amino acids were obtained at room temperature with BF3 ⋅ OEt2 or PTSA/silica gel after short reaction times, or with PTSA/MgSO4 after extended periods. Cyclization of α,α-disubstituted amino acids is less successful.

acid catalysis - oxazolidin-5-one - amino acids - mild conditions

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