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Synthesis 1996; 1996(2): 297-304
DOI: 10.1055/s-1996-4185
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Towards the Total Synthesis of Ambruticin: Preparation of the Fully Functionalised Right-Hand Portion Using the Intramolecular Silyl-Modified Sakurai (ISMS) Annulation

István E. Markó* , Daniel J. Bayston
  • *Université Catholique de Louvain, Département de Chimie, Laboratoire de Chimie Organique, Bâtiment Lavoisier, Place Louis Pasteur 1, B-1348 Louvain-La-Neuve, Belgium, Fax +32(10)472788; E-mail marko@CHOR.UCL.AC.BE
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Publication Date:
31 December 2000 (online)

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The concise synthesis of the fully functionalised right-hand dihydropyran subunit of the antifungal antibiotic ambruticin (1), using the ISMS annulation as the key-step, is described.

ambruticin - intramolecular silyl-modified Sakurai condensation - oxonium ion - dihydropyran

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