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Synthesis 1992; 1992(11): 1179-1184
DOI: 10.1055/s-1992-26329
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Synthesis and Biological Activity of Enantiomeric Oxapenemcarboxylic Acids

Hans Rudolf Pfaendler* , Thomas Neumann, Rüdiger Bartsch
  • *Institute of Organic Chemistry, University of München, Karlstraße 23, D-8000 München, Germany
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Publication Date:
17 September 2002 (online)

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The synthesis of enantiomerically pure potassium (5R)- and (5S)-trans-2-tert-butyl-6-hydroxymethyloxapenem-3-carboxylates is reported. Surprisingly, both enantiomers were active antibiotics and ß-lactamase inhibitors.

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