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Synthesis 1992; 1992(11): 1053-1054
DOI: 10.1055/s-1992-26296
short paper
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An Improved Synthesis of 5-Halopyrimidines: Reaction of α-Halo Ketones with Nitriles

A. García Martínez* , A. Herrera Fernández, Dolores Molero Vilchez, M. Hanack, L. R. Subramanian
  • *Departemento de Química Orgánica, Facultad de Ciencias Químicas, Universidad Complutense, E-28040 Madrid, Spain
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Publication Date:
17 September 2002 (online)

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The reaction of alkyl and aryl α-halomethyl ketones 1 with aliphatic and aromatic nitriles 2 in the presence of trifluoromethanesulfonic anhydride affords substituted 5-halopyrimidines 3 in good yields (55-91%).

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