Synthesis 1990; 1990(4): 327-328
DOI: 10.1055/s-1990-26866
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General and Efficient Synthesis of 1,1,1-Trichloro-2-alkanols

Raffaella Ferraccioli* , Carlo Gallina, Cesare Giordano
  • *C. N. R. Centro Sintesi e Stereochimica Speciali Sistemi Organici, Via Golgi 19, Milan, Italy
Further Information

Publication History

Publication Date:
17 September 2002 (online)

1,1,1-Trichloroalkanols were readily obtained in good yields by reaction of trichloroacetic acid with aldehydes in hexamethylphosphoric triamide. 1,3-Dimethyl-2-imidazolidinone was found to be useful as an alternate solvent giving, however, lower yields.

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