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Synthesis 1989; 1989(6): 414-418
DOI: 10.1055/s-1989-27270
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Palladium-Catalyzed Synthesis of Didehydroamino Acid Derivatives

Anne-Sofie Carlström* , Torbjörn Frejd
  • *Organic Chemistry 2, Chemical Center, University of Lund, P.O. Box 124, S-22100 Lund, Sweden
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Publication History

Publication Date:
17 September 2002 (online)

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The palladium-catalyzed coupling of 2-amidoacrylates with aryl iodides under phase-transfer conditions yields aromatic (Z)-didehydroamino acid derivatives, which give various protected aromatic amino acids via catalytic hydrogenation using Pd/C or the Wilkinson catalyst.

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