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Synthesis 1986; 1986(1): 41-42
DOI: 10.1055/s-1986-31469
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A New Carbacyclin Synthesis

Bärbel Bennua* , Helmut Dahl, Helmut Vorbrüggen
  • *Research Laboratories, Schering AG, Berlin - Bergkamen, D-1000 Berlin 65, Germany
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Publication History

Publication Date:
20 August 2002 (online)

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After opening of substituted Corey lactones by alkali, acidification and Jones oxidation to the γ-keto acids, reaction with triphenyl-(phenyliminovinylidene)-phosphorane afforded in 50% overall yield the corresponding unsaturated bicyclo[3.3.0]octane-1-one derivatives, which could be readily reduced to the saturated bicyclic ketones.

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