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Synthesis 1985; 1985(12): 1149-1151
DOI: 10.1055/s-1985-31458
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An Efficient Method for the Preparation of 2-Thioxotetrahydro-1,3-oxazines

Ferenc Fülöp* , György Csirinyi, Gábor Bernáth, József A. Szabó
  • *Institute of Pharmaceutical Chemistry, University Medical School, H-6720 Szeged, Eötvös u. 6, Hungary
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Publication Date:
27 September 2002 (online)

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2-Thioxotetrahydro-1,3-oxazole and 2-thioxotetrahydro-1,3-oxazines (including cycloalkane-fused derivatives) are prepared by reaction of 2- or 3- aminoalkanols, respectively, with carbon disulfide and triethylamine and condensation of the triethylammonium dithiocarbamates thus obtained with ethyl carbonochloridate and triethylamine. The yields of the 2-thioxo-1,3-O,N-heterocycles thus prepared are considerably higher than those obtained by the earlier methods.

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