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Synthesis 2004(18): 3011-3016
DOI: 10.1055/s-2004-834875
DOI: 10.1055/s-2004-834875
PAPER
© Georg Thieme Verlag Stuttgart · New York
Synthesis of N α-Fmoc N,N′-bis-Boc-5-, 6- and 8-guanyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acid (5-GTIC, 6-GTIC and 8-GTIC)
Further Information
Received
13 July 2004
Publication Date:
21 October 2004 (online)
Publication History
Publication Date:
21 October 2004 (online)
Abstract
N α-Fmoc N,N′-bis-Boc-5-, 6- and 8-guanyl-Tic-OH (5-, 6- and 8-GTIC), three conformationally constrained amino acids with basic properties, have been synthesized by microwave irradiation. These amino acids combine the basic features of arginine with the aromatic features of phenylalanine and can be utilized as functional tools in peptide-based structure-activity studies.
Key words
unconventional amino acid - microwave - synthesis - GTIC
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