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Synthesis 2003(11): 1667-1670
DOI: 10.1055/s-2003-40883
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Chiral Analogues of FTY720 and its Phosphate

Klaus Hinterding*a, Sylvain Cottensa, Rainer Alberta, Frederic Zecria, Peter Buehlmayera, Carsten Spankaa, Volker Brinkmanna, Peter Nussbaumerb, Peter Ettmayerb, Klemens Hoegenauerb, Nathanael Grayc, Shifeng Panc
a Novartis Institutes for Biomedical Research, S507.409, 4002 Basel, Switzerland
Fax: +41(61)3246735; e-Mail: klaus.hinterding@pharma.novartis.com;
b Novartis Forschungsinstitut GmbH, Brunner Str. 59, 1235 Wien, Austria
c Novartis Institute for Functional Genomics Inc,, 10675 John Jay Hopkins Drive, San Diego CA 92121, USA
Further Information

Publication History

Received 16 May 2003
Publication Date:
25 July 2003 (online)

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Abstract

Efficient and versatile protocols for the synthesis of chiral analogues of the novel immunomodulator FTY720 and its phosphate are described. These synthetic procedures allow for broad structural variation and deliver essential tools to further elucidate FTY720’s novel mechanism of action.

Key words

phosphates - sphingolipids - stereoselective synthesis - drugs - chiral auxiliaries

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1

These authors contributed equally to this study.

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