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Synthesis 2003(5): 0717-0722
DOI: 10.1055/s-2003-38081
DOI: 10.1055/s-2003-38081
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York
Synthesis of Pyridine-Fused Ring Systems from β-Chloroacroleins: A Comparison of Three Different Pathways
Further Information
Received
17 December 2002
Publication Date:
21 March 2003 (online)
Publication History
Publication Date:
21 March 2003 (online)
Abstract
Three different pathways for the access of pyridine-fused ring systems are described: 1) a Sonogashira coupling of β-chloroacroleins followed by cyclization of the corresponding imines; 2) the same coupling reaction followed by cyclization of the corresponding oximes; and 3) a palladium-catalyzed iminoannulation of internal alkynes.
Key words
β-chloroacroleins - Sonogashira coupling - heteroannulation - imines
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