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Synthesis 2001(9): 1313-1320
DOI: 10.1055/s-2001-15215
PAPER
© Georg Thieme Verlag Stuttgart · New York

Synthesis of N α -Tetrachlorophthaloyl (TCP)-Protected Amino Acids under Microwave Irradiation (MWI)

Esther Cros, Marta Planas, Eduard Bardají*
Department of Chemistry, University of Girona, 17071 Girona, Spain
Fax: +34(972)418150; e-Mail: dqebr@xamba.udg.es;
Further Information

Publication History

Received 10 January 2001
Publication Date:
24 September 2004 (online)

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Abstract

A range of N α-tetrachlorophthaloyl protected amino acids have been synthesized by an easy and efficient condensation procedure of the corresponding amino acid and tetrachlorophthaloyl anhydride under irradiation in an unmodified commercial microwave oven.

Key words

amino acids - microwave irradiation - protecting groups - phthalimide - tetrachlorophthaloyl

    References and Notes

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11

PAL, peptide amide linker: 5-(4-aminomethyl-3,5-dimethoxyphenoxy)valeric acid; PEG-PS, polyethylene glycol-polystyrene (graft support).

12

Continuous heating resulted in burning of the reaction mixture.