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Synthesis 2011(11): 1792-1798  
DOI: 10.1055/s-0030-1260023
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Ligand-Free Copper Oxide Nanoparticle-Catalyzed Sonogashira Coupling Reaction

Yu Yuan*a, Haitao Zhua, Dongbo Zhao*b, Li Zhanga
a College of Chemistry & Chemical Engineering, Yangzhou University, Jiangsu Province 225002, P. R. of China
e-Mail: yyuan@yzu.edu.cn;
b Bayer Technology & Engineering (Shanghai) Co., Ltd., F3 Area, Mu Hua Road, Shanghai Chemical Industry Park, Shanghai 201507, P. R. of China
Fax: +82(21)67120397; e-Mail: tony.zhao@bayertechnology.com;
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Publication History

Received 7 March 2011
Publication Date:
05 May 2011 (online)

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Abstract

The catalytic Sonogashira coupling reaction of terminal alkynes and aryl halides is developed using copper(II) oxide nanoparticles as catalyst in dimethyl sulfoxide. The procedure is experimentally simple, general, efficient, and free from addition of external cocatalysts or chelating ligands.

Key words

copper(II) oxide nanoparticles - Sonogashira coupling - ligand-free - nano catalyst

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