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Synthesis 2010(1): 110-114  
DOI: 10.1055/s-0029-1217085
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Chemoenzymatic Synthesis of Substituted 1H-Inden-1-ones Using Lipases

Ana Rioz-Martínez, Gonzalo de Gonzalo, Vicente Gotor*
Departamento de Química Orgánica e Inorgánica, Instituto Universitario de Biotecnología de Asturias, Universidad de Oviedo, 33006 Oviedo, Spain
Fax: +34(98)5103448; e-Mail: vgs@fq.uniovi.es;
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Publication History

Received 30 July 2009
Publication Date:
26 October 2009 (online)

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Abstract

A practical and straightforward chemoenzymatic synthesis of novel acetoxy- and hydroxy-1H-inden-1-ones starting from commercial indan-1-ones is described. By using different lipases, the final step of the preparation can be performed with high conversion working under mild reaction conditions. The desired compounds, which present a great interest since they can be employed as target substrates in enzymatic activity detection assays, were obtained in good overall yields.

Key words

enzymes - elimination - hydrolyses - ketones - fluorogenic compounds

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