Straightforward Functionalization
of 3,5-Dichloro-2-pyrazinones under Simultaneous Microwave
and Ultrasound Irradiation

Davide Garella; Silvia Tagliapietra; Vaibhav P. Mehta; Erik Van der Eycken; Giancarlo Cravotto

doi:10.1055/s-0029-1217065

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Synthesis 2010(1): 136-140
DOI: 10.1055/s-0029-1217065

PAPER

Straightforward Functionalization of 3,5-Dichloro-2-pyrazinones under Simultaneous Microwave and Ultrasound Irradiation

Davide Garella^a, Silvia Tagliapietra^a, Vaibhav P. Mehta^b, Erik Van der Eycken^b, Giancarlo Cravotto*^a
^a Dipartimento di Scienza e Tecnologia del Farmaco, Università degli Studi di Torino, Via P. Giuria 9, 10125 Torino, Italy
Fax: +39(011)6707687; e-Mail: giancarlo.cravotto@unito.it;
^b Laboratory for Organic and Microwave-Assisted Chemistry, Department of Chemistry, Katholieke Universiteit Leuven, Celestijnenlaan 200F, 3001 Leuven, Belgium

Further Information

Publication History

Received 6 July 2009
Publication Date:
26 October 2009 (online)

Abstract
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Abstract

Heck reactions and Suzuki-Miyaura cross-couplings with relatively poorly reactive 3,5-dichloro-2-pyrazinones were studied at the same temperature under conventional heating, dielectric heating (MW) and simultaneous MW/US irradiation. This comparative study showed a synergic effect of combined MW and US irradiation resulting in a much higher reaction yield, at the same time avoiding side reactions and partial degradation that is otherwise observed under conventional heating.

Key words

pyrazinones - ultrasound - microwaves - simultaneous irradiation - Heck reaction - Suzuki cross-coupling

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