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Synfacts 2008(9): 0953-0953
DOI: 10.1055/s-2008-1078663
DOI: 10.1055/s-2008-1078663
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Cu-Catalyzed Tandem Friedel-Crafts/Henry Reaction
T. Arai*, N. Yokoyama
Chiba University, Japan
Further Information
Publication History
Publication Date:
22 August 2008 (online)
Significance
This report describes one of the first successful tandem Friedel-Crafts/Henry (FCH) reactions that provide acyclic chiral products. The most significant point of this account is the predominant formation of only three diastereomers of the three-component reaction products (3) that bear three contiguous stereocenters.