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Synfacts 2008(9): 0902-0902  
DOI: 10.1055/s-2008-1077996
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Salinamide A

Contributor(s): Philip Kocienski
L. Tan, D. Ma*
Shanghai Institute of Organic Chemistry, P. R. of China
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Publication History

Publication Date:
22 August 2008 (online)

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Significance

Salinamide A was isolated from various Streptomyces species. It inhibits bacterial RNA polymerases without affecting human RNA polymerases. It is also a potent anti-inflammatory agent. The apex of the synthesis was the chemistry used to construct the phenylglycine fragment D.