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Synfacts 2008(9): 0905-0905  
DOI: 10.1055/s-2008-1077991
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of (±)-Dysibetaine

Contributor(s): Philip Kocienski, Zofia Komsta
J. Isaacson, M. Loo, Y. Kobayashi*
University of California at San Diego, La Jolla, USA
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Publication History

Publication Date:
22 August 2008 (online)

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Significance

(-)-Dysibetaine was isolated from the marine sponge Dysidea herbacea. The compound potentially interacts with the glutamate receptors in the central nervous system. The key step of the synthesis is the four-center-three-component Ugi reaction (D → F).