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Synfacts 2008(9): 0900-0900  
DOI: 10.1055/s-2008-1077985
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of (-)-Pestalotiopsin A

Contributor(s): Philip Kocienski, Arndt W. Schmidt
K.-i. Takao, N. Hayakawa, R. Yamada, T. Yamaguchi, U. Morita, S. Kawasaki, K.-i. Tadano*
Keio University, Yokohama, Japan
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Publication History

Publication Date:
22 August 2008 (online)

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Significance

(+)-Pestalotiopsin A shows promising cytotoxic and immunosuppressive activities. The present paper exhibits the first enantioselective synthesis of (-)-pestalotiopsin A, thereby proving the absolute stereochemistry for the first time.