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Synfacts 2008(6): 0601-0601  
DOI: 10.1055/s-2008-1072621
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Enantioselective Cyanosilylation of Aldehydes Catalyzed by A Chiral Salen-Aluminum(III) Complex

Contributor(s): Hisashi Yamamoto, Pingfan Li
Z. Zeng, G. Zhao, Z. Zhou*, C. Tang
Nankai University, Tianjin, P. R. of China
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Publication History

Publication Date:
21 May 2008 (online)

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Significance

Enantioselective cyanosilylation reactions of several aldehydes (mainly aromatic aldehydes) are realized through the combined use of a salen-aluminum(III) complex as Lewis acid catalyst (1 mol% loading) and trioctylphosphine oxide as Lewis base catalyst (10 mol% loading). Good yields are always obtained, while the enan­tiomeric excess ranges from modest to good.